Macular edema is the condition characterized by abnormal leakage and accumulation of fluid that forms blister in the layer of macula. The macula is an oval-shaped pigmented area near the center of retina. This blister causes the macula to swell and thicken that causes distortion of vision. Although macular edema has numerous causes, the most common cause is diabetes. Other causes include, age-related macular degeneration, replacement of lenses in treatment of cataract, chronic uveitis and intermediate uveitis, blockage of vein in the retina, and congenital diseases including retinitis pigmentosa and retinoschisis.

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