Opana ER 10 mg is a medicine approved by the FDA for serious surgical pain. It is strictly a prescribed medicine with a chance of being misused.Opana ER 10 mg is a medicine approved by the FDA for serious surgical pain. It is strictly a prescribed medicine with a chance of being misused.Opana ER 10 mg is a medicine approved by the FDA for serious surgical pain. It is strictly a prescribed medicine with a chance of being misused.