Can you take Vicodin and OxyContin together & Which one is stronger tha decided due to compare Vicodin vs OxyContin for pain relief. Hydrocodone and oxycodone are both Schedule II semi-synthetic opioids prescribed to relieve moderate to severe pain, and chemically, they are very similar. While opioids work well as pain relievers or analgesics and bring feelings of extreme relaxation and euphoria, they also have significant dangers of addiction and death.